HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Thrombin generation and activated protein C resistance in patients with essential thrombocythemia and polycythemia vera
نویسندگان
چکیده
1Department of Internal Medicine, Laboratory for Clinical Thrombosis and Haemostasis, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; 2Thrombosis and Hemostasis Center, Department of Hematology-Oncology, Ospedali Riuniti di Bergamo, Bergamo, Italy; 3Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht University, Maastricht, The Netherlands; 4Research Foundation, Ospedali Riuniti di Bergamo, Bergamo, Italy; and 5Department of Internal Medicine, Division of Haematology, University Hospital Maastricht, Maastricht, The Netherlands
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Thrombohemorrhagic complications are a major cause of morbidity and mortality in patients with essential thrombocythemia (ET) and polycythemia vera (PV). The pathogenesis of these complications is not completely clarified. Several studies have described abnormalities of red blood cells and platelets in these patients. However, no studies are available on changes in the polymorphonuclear leukocy...
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Leukocyte (WBC) count has been recently identified as an independent predictor of major thrombosis in both essential thrombocythemia (ET) and polycythemia vera (PV). However, whether leukocytosis should be simply considered a marker for vascular disease or whether elevated WBC levels actually contribute directly to causing such disorders is presently matter of many studies. By adopting epidemio...
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